强直性脊柱炎患者治疗前后免疫功能和细胞因子的变化及意义(新)

强直性脊柱炎患者治疗前后免疫功能和细胞因子的变化及意义[摘要]目的:分析强直性脊柱炎患者治疗前后免疫功能和细胞因子的变化及意义方法选取2015年7月至2017年6月期间在我院进行治疗的80例强直性脊柱炎患者进行研究,所有患者采用益赛普和西乐葆治疗。通过BASDAI和BASFI的VAS评分比较患者治疗前后的症状体征,并测定患者治疗前后血清中IL-4、IL-6、IL-8、IL-10、IgG1、IgG2、IgG3、IgG4、IgA、SIgA、IgM水平。结果与治疗前相比,治疗后患者的BASDAI和BASFI的VAS评分均显著,降低差异有统计学意义(P < 0.05)。患者治疗后的IL-4、IL-10均高于治疗前,差异具有统计学意义(P < 0.05),治疗后的IL-6、IL-8均低于治疗前,差异有统计学意义(P < 0.05)。患者治疗后的IgG1、IgG3、IgA高于治疗前,差异具有统计学意义(P<0.05);治疗前后的IgG2、IgG4、SIgA、IgM相比,差异均无统计学意义(P>0.05)。患者的IL-4 与BASDAI 呈负相关(P<0.05),IgG1和IgG3与BASDAI、BASFI 均呈正相关(P<0.05),其余指标与BASDAI和BASFI 均无相关关系。结论强直性脊柱炎患者存在细胞因子异常和免疫球蛋白失调,治疗后有所改善,部分指标与其症状体征具有相关性。

【关键词】强直性脊柱炎;免疫功能;免疫球蛋白;细胞因子

Changes and significance of immune function and cytokines in patients with ankylosing

spondylitis before and after treatment

[Abstract] Objective Toanalysethechanges and significance of immune function and cytokines in patients with ankylosing spondylitis before and after treatment Methods 80 cases of ankylosing spondylitis patients treated in our hospital from July 2015 to June 2017 were studied,andall patients were treated with etanercept and celebrex treatment. The symptoms and signs of the patients before and after treatment were compared by the V AS scores of BASDAI and BASFI.The serum levels of IL-4, IL-6, IL-8, IL-10, IgG1, IgG2, IgG3, IgG4, IgA, SIgA, IgM in serum before and after treatment were measured.Results Compared with before treatment, the BASDAI and BASFI scores of V AS patients were significantly lower, the difference was statistically significant (P < 0.05). The IL-4 and IL-10 of the patients after treatment were higher than before treatment, the difference was statistically significant (P < 0.05), the IL-6 and IL-8 after treatment were lower than before treatment, the difference was statistically significant (P < 0.05). The IgG1, IgG3 and IgA of the patients after treatment were higher than before treatment, the difference was statistically significant (P<0.05). There were no statistically significant differences in IgG2, IgG4, SIgA and IgM before and after treatment (P>0.05). The IL-4 of patients was negatively correlated with BASDAI (P<0.05), IgG1 and IgG3 were positively correlated with BASDAI and BASFI (P<0.05), and the other indexes were not related to BASDAI and BASFI.Conclusion Patients with ankylosing spondylitis have abnormal cytokines and immune globulin disorders, which have improved after treatment, and some of the indicators are related to their symptoms and signs. [Key words]Ankylosing spondylitis; immune function; immunoglobulin; cytokine

强直性脊柱炎是一种慢性进展性炎症性骨关节病,主要表现为外周关节炎、骶髂关节炎以及侵犯中轴关节[1]。该病多发于青壮年男性,其患病率较高。目前对于强直性脊柱炎的发病机制尚不明确,而目前的研究结果表明,其发病机制的中免疫过程与患者T细胞活性、功能的变化有着密切的相关性,其中炎症及细胞因子在AS的发病中发挥了重要作用,抑制细胞因子的释放对强直性脊柱炎具有治疗价值[2]。本研究选取在我院接诊的强直性脊柱炎患者进行研究,分析其治疗前后免疫功能和细胞因子的变化及意义,现报道如下。

1 材料与方法

1.1 一般资料

强直性脊柱炎患者治疗前后免疫功能和细胞因子的变化及意义(新)相关文档

最新文档

返回顶部