MMAD hydrochloride_173441-26-4_DataSheet_MedChemExpress
Product Data Sheet
Product Name:
CAS No.:
Cat. No.:
MWt:
Formula:
Purity :MMAD hydrochloride173441-26-4HY-79105807.53C41H67ClN6O6S>98%
Solubility:
Mechanisms: Pathways:Cell Cycle/DNA Damage; Target:Microtubule/Tubulin
Pathways:Antibody-drug conjugates/ADCs Related; Target:ADCs cytotoxin
Biological Activity:
Monomethyl auristatin D Hcl (MMAD Hcl), a potent tubulin inhibitor, is a toxin payload in antibody drugconjugate.
IC50 value:
Target: Tubulin; ADCs toxin
For comparison purposes, the ADC A1 -mc-MMAD and/or A1 -vc-MMAD were used. The linker payload, mc-MMAD (6-maleimidocaproyl-monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibodythrough a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule. The linkerpayload mc- Val-Cit-PABA-MMAD or vc-MMAD (maleimidocapronic -valine-citruline-p-
aminobenzyloxycarbonyl- monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibodythrough a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule (Antibody-drugconjugates Patent: WO 2013068874 A1).
...
References:
[1]. Antibody-drug conjugates Patent: WO 2013068874 A1
Caution: Not fully tested. For research purposes only
Medchemexpress LLC
http://www.wendangwang.com
11DeerParkDrive, Suite 102D Monmouth Junction, NJ 08852,USA
ail: info@http://www.wendangwang.com Web: http://www.wendangwang.comEm
