Sensors 2010, 10, 4855-4886; doi:10.3390/s100504855 ISSN 1424-8220

http://www.wendangwang.com/journal/sensors

Review sensors OPEN ACCESS

A Comprehensive Review of Glucose Biosensors Based on

Nanostructured Metal-Oxides

Md. Mahbubur Rahman 1, A. J. Saleh Ahammad 1, Joon-Hyung Jin 2, Sang Jung Ahn 3

and Jae-Joon Lee 1,2,4,*

1 Department of Advanced Technology Fusion, Konkuk University, Seoul 143-701, Korea;

E-Mails: mahbub@konkuk.ac.kr (M.M.R.); saleh203@konkuk.ac.kr (A.J.S.A.)

2 KFnSC Center, Konkuk University, Seoul 143-701, Korea; E-Mail: jhjin@konkuk.ac.kr

3 Korea Research Institute of Standard and Science, Yuseong, Daejeon 305-340, Korea;

E-Mail: sjahn@kriss.re.kr

4 Department of Applied Chemistry, Konkuk University, Chungju 380-701, Korea

* Author to whom correspondence should be addressed; E-Mail: jjlee@kku.ac.kr;

Tel.: +82-43-840-3580; Fax: +82-43-851-4169.

Received: 11 March 2010; in revised form: 7 April 2010 / Accepted: 15 April 2010 /

Published: 12 May 2010

Abstract: Nanotechnology has opened new and exhilarating opportunities for exploring

glucose biosensing applications of the newly prepared nanostructured materials.

Nanostructured metal-oxides have been extensively explored to develop biosensors with

high sensitivity, fast response times, and stability for the determination of glucose by

electrochemical oxidation. This article concentrates mainly on the development of different

nanostructured metal-oxide [such as ZnO, Cu(I)/(II) oxides, MnO2, TiO2, CeO2, SiO2,

ZrO2, and other metal-oxides] based glucose biosensors. Additionally, we devote our

attention to the operating principles (i.e., potentiometric, amperometric, impedimetric and

conductometric) of these nanostructured metal-oxide based glucose sensors. Finally, this

review concludes with a personal prospective and some challenges of these nanoscaled

sensors.

Keywords: nanostructured metal-oxides; glucose biosensor; electrochemical principles;

enzymatic sensor; nonenzymatic sensor