2016 CMPF Cell Rep

Article

RapidElevationinCMPFMayActAsaTippingPointinDiabetesDevelopment

GraphicalAbstract

Highlights

d

CMPFissigni cantlyelevatedinbothprediabetesandtype2diabetes

d

RapidelevationincirculatingCMPFmayacceleratediabetesdevelopment

d

CMPFimpairsglucosemetabolismbyintroducingpreferentialfattyacidoxidation

d

CMPFinducesbetacelldysfunctionshownasimpairedinsulinsecretion

Liuetal.,2016,CellReports14,1–12March29,2016ª2016TheAuthors

http://www.wendangwang.com/10.1016/j.celrep.2016.02.079

Authors

YingLiu,KaceyJ.Prentice,

JudithA.Eversley,...,FeihanF.Dai,WeipingJia,MichaelB.Wheeler

Correspondence

wpjia@http://www.wendangwang.com(W.J.),

michael.wheeler@utoronto.ca(M.B.W.)

InBrief

Liuetal.showthatCMPFissigni cantlyelevatedinbothprediabetesandtype2diabetes.RapidelevationinCMPFmayrepresentthetippingpointinbetacellfunction,playingacausalroleintheconversionfromprediabetestotype2

2016 CMPF Cell Rep

diabetes.

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