终结稿 中药注射液中吐温80定性定量测定

14种中药注射剂中吐温80定性定量测定(一)

闫位娟12 李连达2 王建农2 邵立军2 (1.广西右江民族医学院,百色 530001;2.中国中医科学院西苑医院基础医学研究中心,北京 100091) 。

摘要:目的 测定临床报告过敏性休克排名较前的14种中药注射剂中吐温80的含量。方法 硫氰酸钴铵和薄层层析两种方法结合定性判定中药注射剂是否含有吐温80,比色法测定吐温80的含量。结果 脉络宁注射液、参麦注射液、鱼腥草注射液、生脉注射液、复方丹参注射液、穿琥宁注射液中含有吐温80,含量分别为6.22±0.05、4.04±0.04、3.65±0.02、3.47±0.08、2.89±0.07、0.18±0.00mg/ml,其他注射剂未检出吐温80。结论 中药注射剂中吐温80的添加有待加强监督与规范。

关键词:中药注射剂;吐温80;硫氰酸钴铵法;薄层层析法;比色法

Qualitative and Quantitative Determination of Tween80 in Fourteen

Traditional Chinese Medicine Injections

YAN Wei-juan1,2, LI Lian-da2,WANG Jian-nong2,SHAO Li-jun2(1 Guangxi

Youjiang Medical College for Nationality, Baise 533000; 2 Xiyuan

Hospital, China Academ y of Traditional Chinese Medicine, Beijing 100091)

ABSTRACT: OBJECTIVE To determine the content of 14 traditional Chinese medicine injections which rank the top 14 in the anaphylactic shock clinic reports. METHODS Cobalt thiocyanate ammonium color-developing method and silicon thin-layer chromatography qualitatively detect the Tween80 of the traditional Chinese medicine injections, colorimetic determine the content of Tween80. RESULT Mailuoning injection、Sen-Mei injection、the Houttuynia cordata injection、Sheng-Mai injection、compound SM injection、Potassium dehydroandrographolide succinate injection all contain Tween80, the content were respectively 6.22±0.05,4.04±0.04,

3.65±0.02,3.47±0.08,2.89±0.07,0.18±0.00mg/ml,the other injections were not 资助基金:国家十一五科技支撑计划资助(2006BAI14B05).

作者简介:闫位娟(1978- ) ,女,博士研究生,讲师。 Tel: 010(62874069) E-mail: missyan3611@http://www.wendangwang.com.

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