中国汉族冠心病患者乙醛脱氢酶2基因多态性与心肌梗死的相关性研究

第45卷第8期山　东　大　学　学　报　(医　学　版)Vol.45No.8

JOURNALOFSHANDONGUNIVERSITY(HEALTHSCIENCES)2007年8月Aug.2007

文章编号:1671-7554(2007)08-0808-05

中国汉族冠心病患者乙醛脱氢酶2基因多态性与心肌梗死的相关性研究

薛　丽,陈玉国,徐　峰,张　鹤,江春晓,张　运

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(山东大学齐鲁医院1.急诊科;2.心内科,山东济南250012)

　　[摘要]　目的:探讨汉族冠心病患者中乙醛脱氢酶2乙醛脱氢酶2(ALDH2)基因多态性与心肌梗死

(MI)的相关性。方法:对231例冠心病患者采用多聚酶链反应分析ALDH2基因G487A多态性。并根据基因型分两组,ALDH2基因GG型组(n=145)和AAΠAG型组(n=86),比较两组间MI发病率、心血管病传统危险因素和饮酒量等指标的差异,以评价MI的危险因素。结果:ALDH2AAΠAG糖尿病发病率明显高于GG型组,均有统计学意义(P<0.01)。采用多因素心血管病家族史、总胆固醇、糖尿病后,发现AAΠAG型是MI,0.)高血压病这一自变量后AG(3.P=0.03),进一步引入饮酒量和高密度脂蛋白(HDL2C)MI间不再存在相关性(P=0.23)。结论:ALDH2基因AAΠAG型是MI,其可能通过改变血压、饮酒量和HDL2C水平影响MI发病。

[关键词]　心肌梗死;基因;多态性,单核苷酸;乙醛脱氢酶2[中图分类号]　R541.4　　[文献标码识]　A

CorrelationbetweenAldehydedehydrogenase22genepolymorphismsand

myocardialinfarctioninChineseHanpatientswith

coronaryheartdisease

XUELi,CHENYu2guo,XUFeng,ZHANGHe,JIANGChun2xiao,ZHANGYun

(1.DepartmentofEmergency;2.DepartmentofCardiology,QiluHospitalof

ShandongUniversity,Jinan250012,Shandong,China)

[ABSTRACT]　Objective:ToinvestigatethecorrelationbetweentheG487Avariantofaldehydedehydrogenase22(ALDH2)genepolymorphismsandmyocardialinfarctioninChineseHanpatientswithcoronaryheartdisease.Meth2ods:Twohundredandthirty2onepatientswithcoronaryheartdisease,whowereidentifiedbycoronaryangiography,wereenrolledinthisstudy.ThegenotypesofALDH2weredeterminedbythepolymerasechainreactionanddirectsequencing.Thepatientsweredividedintotwogroupsaccordingtothegenotypes:theGGgenotypegroup(n=145)andtheAAΠAGgenotypesgroup(n=86).Thedifferencesbetweenthetwogroupsandtheriskfactorsformyocardialinfarctionwereas2sessed.Results:TheprevalenceofmyocardialinfarctionanddiabetesmellituswassignificantlyhigherintheALDH2AAΠAGgenotypesgroupthanintheGGgenotypegroup(P<0.01),butotherbasicclinicaldataweresimilarbetweenthetwogroups.Afteradjustmentforage,sex,smoking,familyhistoryofcardiovasculardisease,totalcholesterolanddi2abetesmellitususingamulti2variablelogisticregression,theAAΠAGgenotypeswereanindependentriskfactorformyo2cardialinfarction(OR=3.42,P<0.01).However,inclusionofhypertensionasoneoftheindependentvariablesdownplayedtheimportanceoftheALDH2genotype(OR=3.03,P=0.03),andinclusionofhypertension,alcohol

[作者简介]薛丽(1982-),女,硕士研究生,主要从事急性冠脉综合征基础与临床的研究。

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